In vivo and in vitro expertise using magnetic resonance technologies

 

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  imaging mouse brain

In vivo imaging of mouse brain

 

Keywords

  • MR Imaging
  • Metabolism
  • Micro-environment
  • Spectroscopy

 

Technology Market

The Nuclear & Electron Spin Technologies platform (NEST) accommodates cutting-edge magnetic resonance technologies (magnetic resonance imaging, electron paramagnetic resonance and nuclear magnetic resonance) dedicated to studies on biological samples, small animals and humans. These technologies may provide convenient biomarkers for monitoring (pato) physiological parameters and the response to pharmacological treatments.

 

The UCL background 

Nuclear magnetic resonance

  • Metabolomics study on biological samples
  • Saturation transfer difference
  • 2D homonuclear and heteronuclear
  • HRMAS experiment on biopsies

 

Magnetic resonance imaging

  • In vivo anatomical structures with high spatial resolution
  • Metabolism (spectroscopy)
  • Cardiac and vascular imaging
  • Tissue perfusion
  • Diffusion measurement

 

Dynamic nuclear polarization

  • Study of metabolic fluxes using 13C-MRS as biomarker of response (in-vitro and in-vivo)
  • Use of  13C pyruvate and its metabolites as biomarker of metabolism and glycolysis
  • Use of 13C glutamine and its conversion into glutamate to study metabolic shifts
  • Use of hyperpolarized substrates for the stratification of tumors

 

Electron paramagnetic resonance

  • Free radicals characterization, redox status
  • Quantification of melanin / melanoma cells in tissues
  • Dosimetry
  • Tissue oxygenation, oxygen consumption (cells and mitochondria)
  • MRI contrast agent quantification

 

Interested to benefit from these services? 

Please contact:

Fabienne FAUCHET 
Technology Transfer Advisor
+32 10 47 25 49
fabienne.fauchet@uclouvain.be

 

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