Diagnosing endothelial dysfunction to prevent cardiovascular diseases
Cardiovascular diseases prevention
There is an urgent need for a satisfying biomarker to improve risk stratification of patients with silent vascular disease and so prevent an evolution towards a cardiovascular disorder.
The quantitative measurement of nitric oxide bioavailability in vasculature is a novel biomarker of endothelial function will be useful for:
Assessing the efficacy of clinical trials and so improving the safety and clinical utility of new drugs
UCLouvain researchers have set up and validated an efficient process to stabilize and quantify the reaction product of hemoglobin and nitric oxide in erythrocytes in vivo. The paramagnetic α-HbNO complex is measured by Electron Paramagnetic Resonance (EPR) spectroscopy.
Measured α-HbNO levels were strongly correlated with endothelial function. The test was clinically validated in cohorts of healthy volunteers or patients with metabolic syndrome. Significant correlations of α-HbNO levels were established with traditional cardiovascular risk factors, such as the Body Mass Index, levels of glycated hemoglobin, non-HDL cholesterol or triglycerides.
Advantages & applications